Make your MS analysis quantitative without standard substances.

Let’s quantify everything!


In LC/MS the trend is towards collecting as much data as possible – e.g. in drug metabolism or environmental screening.

The most accurate way is to use isotopically labelled standard substances. If these are commercially available, they are expensive.

  • Available isotopically labelled standards are expensive.
  • Standards are not available for most of the substances.
  • Synthesising a standard in-house is time-consuming and tedious.
  • Using structrally similar compounds leads to misleading results – using positional isotope may lead to a misestimation of concentration of 40 times.

To quantify with Quantem you only need your computer, structure of the compound, MS signal and used gradient program.

To make the concentration prediction specific to your method and instrument, the same information for at least 5 compounds with a known concentration is needed. The latter can be internal standards, quality control samples or analytes quantified with standard substances.


Pharmaceutical byproducts, important metabolites, environmental contaminants, etc.



Contact us to test Quantem.

Sounds intriguing?

Who are we?

We are a group of analytical chemistry scientists with experience in mass spectrometry since 2007 from different academic research groups as well as industry.

Prof. Dr. Anneli Kruve
Jaanus Liigand
Piia Liigand
Dr. Karl Kaupmees
Mari Ojakivi


We are located in the Internet, Worldwide. More physically in Tartu, Estonia.

E-mail us

Prof. Dr. Anneli Kruve

Product & Sales

Anneli is an Associate professor in analytical chemistry at Stockholm University and an IT master's student. Her research is focussed on understanding the LC/MS and developing better methods. She believes that novel IT solutions help to make better use of the data that current analysis methods are able to collect.

Jaanus Liigand

Data Science

Jaanus is responsible for developing the concentration prediction model in Quantem software. He is an analytical chemistry PhD fellow with over 3 years of experience with machine learning and he is especially interested in modelling complex processes with modern data science tools. As a marathon runner, he is persistent.

Dr. Karl Kaupmees


Karl is the bridge between research and IT. Besides a PhD in chemistry focusing on solvent effects and molecular modelling, he’s currently finishing his Masters in IT concentrating on data science software product management.

Piia Liigand

HR & Legal

Piia expanded the Quantem model applications to biological matrices, connected positive and negative mode ESI. Piia has hands-on experience and insider insight into the pharmaceutical industry. She has collaborated with Janssen Pharmaceutica and is currently the Head of Quality Control Laboratory at TBD-Biodiscovery (an API production company).

Mari Ojakivi


Mari has developed ionization efficiency measurements in water and methanol for Quantem model. She has learned a lot growing up among family and friends with an entrepreneurial mindset. She is a passionate folk dancer and that makes her a great team player